Article
Can linear regression modeling help clinicians in the interpretation of genotypic resistance data? An application to derive a lopinavir-score.
PloS one - 1 Jan 2011
Cozzi-Lepri Alessandro, Prosperi Mattia C F, Kjær Jesper, Dunn David, Paredes Roger, Sabin Caroline A, Lundgren Jens D, Phillips Andrew N, Pillay Deenan
Abstract excerpt
BACKGROUND: The question of whether a score for a specific antiretroviral (e.g. lopinavir/r in this analysis) that improves prediction of viral load response given by existing expert-based interpretation systems (IS) could be derived from analyzing the correlation between genotypic data and virological response using statistical methods remains largely unanswered. METHODS AND FINDINGS: We used the data of the...
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