Prediction of early and confirmed virological response by genotypic inhibitory quotients for lopinavir in patients naïve for lopinavir with limited exposure to previous protease inhibitors.

doi:10.1016/j.jcv.2005.10.001

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Article

Prediction of early and confirmed virological response by genotypic inhibitory quotients for lopinavir in patients naïve for lopinavir with limited exposure to previous protease inhibitors.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Apr 2006

Torti Carlo, Uccelli Maria Cristina, Quiros-Roldan Eugenia, Gargiulo Franco, Tirelli Valeria, Lapadula Giuseppe, Regazzi Mario, Pierotti Piera, Tinelli Carmine, De Luca Andrea, Patroni Andrea, Manca Nino, Carosi Giampiero

Abstract excerpt

OBJECTIVE: To determine the impact of genotypic inhibitory quotient (GIQ) for lopinavir (LPV) in patients failing HAART with limited antiretroviral exposure. DESIGN: Retrospective analysis of a prospective trial. METHODS: Lopinavir GIQ was calculated as the ratio between the mean trough concentration (C(trough)) and the number of protease mutations using eight different HIV drug resistance mutation lists or...

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PMID: 16280255
DOI: 10.1016/j.jcv.2005.10.001

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