Article
Cross-validated stepwise regression for identification of novel non-nucleoside reverse transcriptase inhibitor resistance associated mutations.
BMC bioinformatics - 3 Oct 2011
Van der Borght Koen, Van Craenenbroeck Elke, Lecocq Pierre, Van Houtte Margriet, Van Kerckhove Barbara, Bacheler Lee, Verbeke Geert, van Vlijmen Herman
Abstract excerpt
BACKGROUND: Linear regression models are used to quantitatively predict drug resistance, the phenotype, from the HIV-1 viral genotype. As new antiretroviral drugs become available, new resistance pathways emerge and the number of resistance associated mutations continues to increase. To accurately identify which drug options are left, the main goal of the modeling has been to maximize predictivity and not...
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