Article
Rules-based HIV-1 genotypic resistance interpretation systems predict 8 week and 24 week virological antiretroviral treatment outcome and benefit from drug potency weighting.
The Journal of antimicrobial chemotherapy - 1 Sept 2009
Zazzi Maurizio, Prosperi Mattia, Vicenti Ilaria, Di Giambenedetto Simona, Callegaro Annapaola, Bruzzone Bianca, Baldanti Fausto, Gonnelli Angela, Boeri Enzo, Paolini Elisabetta, Rusconi Stefano, Giacometti Andrea, Maggiolo Franco, Menzo Stefano, De Luca Andrea
Abstract excerpt
OBJECTIVES: To test retrospectively the ability of four freely available rules-based expert systems to predict short- and medium-term virological outcome following an antiretroviral treatment switch in pre-treated HIV-1 patients. METHODS: The HIV-1 genotype interpretation systems (GISs) HIVdb, ANRS, Rega and AntiRetroScan were tested for their accuracy in predicting response to highly active antiretroviral...
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