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Article

Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice.

Blood - 12 Jan 2012

Liu Yin, Belkina Natalya V, Park Chung, Nambiar Raj, Loughhead Scott M, Patino-Lopez Genaro, Ben-Aissa Khadija, Hao Jian-Jiang, Kruhlak Michael J, Qi Hai, von Andrian Ulrich H, Kehrl John H, Tyska Matthew J, Shaw Stephen

Abstract excerpt

ERM (ezrin, radixin moesin) proteins in lymphocytes link cortical actin to plasma membrane, which is regulated in part by ERM protein phosphorylation. To assess whether phosphorylation of ERM proteins regulates lymphocyte migration and membrane tension, we generated transgenic mice whose T-lympho...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22106344
DOI: 10.1182/blood-2011-07-368860
PMCID: PMC3257010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22106344-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice.PMID 22106344Read ↗

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Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout.Semantic proximity Read ↗

Ezrin tunes T‐cell activation by controlling Dlg1 and microtubule positioning at the immunological synapseSemantic proximity Read ↗

Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an autoinhibitory linker.Semantic proximity Read ↗

Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cellsSemantic proximity Read ↗

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