Article
In vitro insulin-like growth factor I interaction with cartilage cells derived from postnatal animals.
Hormone research - 1 Jan 1990
Demarquay D, Dumontier M F, Tsagris L, Bourguignon J, Nataf V, Corvol M T
Abstract excerpt
This paper reports data on the in vitro effects of insulin-like growth factor I (IGF-I) and basic fibroblast growth factor (bFGF) on the phenotypic expression of epiphyseal chondrocytes grown in serum-free (SF) culture medium. bFGF mostly stimulates chondrocyte DNA and inhibits sulfated proteoglycan synthesis and type II collagen mRNA. On the contrary, IGF-I is poorly mitogenic but strongly stimulates protein...
Topics
- Animals
- Collagen
- DNA
- Fibroblast Growth Factor 2
- Gene Expression
- Growth Plate
- Insulin-Like Growth Factor I
- Phenotype
- Proteoglycans
- RNA, Messenger
- Sulfates