Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease.

doi:10.1371/journal.pone.0087523

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Article

Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease.

PloS one - 1 Jan 2014

Petta Salvatore, Miele Luca, Bugianesi Elisabetta, Cammà Calogero, Rosso Chiara, Boccia Stefania, Cabibi Daniela, Di Marco Vito, Grimaudo Stefania, Grieco Antonio, Pipitone Rosaria Maria, Marchesini Giulio, Craxì Antonio

Abstract excerpt

BACKGROUND AND AIMS: Variant in glucokinase regulatory protein (GCKR), associated with lipid and glucose traits, has been suggested to affect fatty liver infiltration. We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype. METHODS: In 366 consecutive NAFLD patients (197 from Sicily, and 169...

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Identifiers

PMID: 24498332
DOI: 10.1371/journal.pone.0087523
PMCID: PMC3911959

Genes

GCKR
PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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