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Article

HMGB1 Promotes Drug Resistance in Osteosarcoma

19 Nov 2011

Abstract excerpt

Osteosarcoma is the most commonly occurring bone cancer in children and adolescents. Unfortunately, treatment failures are common due to the development of chemoresistance, for which the underlying molecular mechanisms remain unclear. In this study, we implicate the DNA-binding protein HMGB1, which also exerts immunoregulatory effects in its secreted form, in the development of drug resistance in osteosarcoma....

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PMID: 22102692
DOI: 10.1158/0008-5472.can-11-2001

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