Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes.

The Journal of biological chemistry - 6 Aug 2010

Dudek Katarzyna A, Lafont Jérôme E, Martinez-Sanchez Aida, Murphy Christopher L

Abstract excerpt

miRNAs have been shown to be essential for normal cartilage development in the mouse. However, the role of specific miRNAs in cartilage function is unknown. Using rarely available healthy human chondrocytes (obtained from 8 to 50 year old patients), we detected a most highly abundant primary miRNA H19, whose expression was heavily dependent on cartilage master regulator SOX9. Across a range of murine tissues,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Chondrocytes

Share to Collagen Type II

Share to MicroRNAs

Share to Models, Biological

Source

Open in PubMed Open full text

Identifiers

PMID: 20529846
DOI: 10.1074/jbc.M110.111328
PMCID: PMC2915673

Genes

SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes.PMID 20529846Read ↗

The role of H19/miR-675 in chondrocyte functionSemantic proximity Read ↗

Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasisSemantic proximity Read ↗

Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in miceSemantic proximity Read ↗

Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditionsSemantic proximity Read ↗

miR-1247 functions by targeting cartilage transcription factor SOX9.Semantic proximity Read ↗

Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).Semantic proximity Read ↗

Brief Report: Importance of SOX8 for In Vitro Chondrogenic Differentiation of Human Mesenchymal Stromal CellsSemantic proximity Read ↗

Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritisSemantic proximity Read ↗

Long noncoding RNA H19 accelerates tenogenic differentiation by modulating miR-140-5p/VEGFA signalingSemantic proximity Read ↗

MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylationSemantic proximity Read ↗

SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesisSemantic proximity Read ↗

Stage-Specific miRs in Chondrocyte Maturation: Differentiation-Dependent and Hypertrophy-Related miR Clusters and the miR-181 FamilySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.