Concentration-response curves for ethylene-oxide-induced heritable translocations and dominant lethal mutations.

doi:10.1002/em.2850160209

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Article

Concentration-response curves for ethylene-oxide-induced heritable translocations and dominant lethal mutations.

Environmental and molecular mutagenesis - 1 Jan 1990

Generoso W M, Cain K T, Cornett C V, Cacheiro N L, Hughes L A

Abstract excerpt

Male mice were subjected to repeated inhalation exposures to different concentrations (165, 204, 250, or 300 ppm) of ethylene oxide (EtO) during an 8.5-week period. Transmitted clastogenic effects of these exposures were measured in terms of induction of dominant lethal mutations and heritable tr...

Topics

Administration, Inhalation
Animals
Dose-Response Relationship, Drug
Ethylene Oxide
Incidence
Male
Mice
Mice, Inbred C3H
Mutagens
Mutation
Translocation, Genetic

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