Article
Genetic aspects of susceptibility, severity, and clinical expression in ankylosing spondylitis.
Current opinion in rheumatology - 1 Jul 2002
Brown Matthew A, Crane Alison M, Wordsworth B Paul
Abstract excerpt
While twin studies have previously demonstrated high heritability of susceptibility to ankylosing spondylitis (AS), it is only recently that the involvement of genetic factors in determining the severity of the disease has been demonstrated. The genes involved in determining the rate of ankylosis in AS are likely to be different from those involved in the underlying immunologic events, and represent important...
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