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Chaperone Mediated Autophagy Substrates and Components in Cancer

12 Feb 2021

Abstract excerpt

Chaperone-mediated autophagy (CMA) represents a specific way of lysosomal protein degradation and contrary to macro and microautophagy is independent of vesicles formation. The role of CMA in different physiopathological processes has been studied for several years. In cancer, alterations of the CMA principal components, Hsc70 and Lamp2A protein and mRNA levels, have been described in malignant cells. However,...

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PMID: 33643916
DOI: 10.3389/fonc.2020.614677

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