Article
Genotoxicity assessment of piperitenone oxide: An in vitro and in silico evaluation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Aug 2017
Di Sotto Antonella, Di Giacomo Silvia, Abete Lorena, Božović Mijat, Parisi Olga A, Barile Fabio, Vitalone Annabella, Izzo Angelo A, Ragno Rino, Mazzanti Gabriela
Abstract excerpt
Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus test, the comet assay and the computational prediction by Toxtree and VEGA tools. Under our experimental conditions, the monoterpene showed to induce both point...
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