Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toxicity evaluation of main zopiclone impurities based on quantitative structure-activity relationship models and in vitro tests.

Journal of applied toxicology : JAT - 1 Feb 2023

Yin Jie, Wen Hairuo, Chen Hua

Abstract excerpt

Toxicity evaluation of main zopiclone impurities can provide a basis for safety assessment and quality standards of zopiclone. In this study, the impurity profile of zopiclone was analyzed using forced degradation and related substances of zopiclone tablets using high-performance liquid chromatography (HPLC). Furthermore, various quantitative structure-activity relationship (QSAR) models were used to compare the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, High Pressure Liquid
Share to Drug Contamination

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Mutation

Share to Quantitative Structure-Activity Relationship

Share to Zebrafish

Source

Identifiers

PMID: 35945809
DOI: 10.1002/jat.4376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toxicity evaluation of main zopiclone impurities based on quantitative structure-activity relationship models and in vitro tests.PMID 35945809Read ↗

Determination of the impurities in drug products containing montelukast and in silico/in vitro genotoxicological assessments of sulfoxide impurity.Semantic proximity Read ↗

In silico and in vitro genotoxicity evaluation of levofloxacin n-oxide, an impurity in levofloxacin.Semantic proximity Read ↗

Cupressus sempervirens Essential Oil: Exploring the Antibacterial Multitarget Mechanisms, Chemcomputational Toxicity Prediction, and Safety Assessment in Zebrafish EmbryosSemantic proximity Read ↗

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 BioactivationSemantic proximity Read ↗

6PPD, Not 6PPD-Quinone, Induced Serious Zebrafish Eye Damage by Disrupting the Thyroid Signaling PathwaySemantic proximity Read ↗

Genotoxicity of quinocetone, cyadox and olaquindox in vitro and in vivo.Semantic proximity Read ↗

Regulatory progress, toxicology, and public concerns with 2,4-D: Where do we stand after two decadesSemantic proximity Read ↗

Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural TestSemantic proximity Read ↗

Teratogenic Potential of Antiepileptic Drugs in the Zebrafish ModelSemantic proximity Read ↗

Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines.Semantic proximity Read ↗

Matrine and Oxymatrine: evaluating the gene mutation potential using in silico tools and the bacterial reverse mutation assay (Ames test).Semantic proximity Read ↗

Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analoguesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.