Article
Beta-catenin accelerates human papilloma virus type-16 mediated cervical carcinogenesis in transgenic mice.
PloS one - 1 Jan 2011
Bulut Gülay, Fallen Shannon, Beauchamp Elspeth M, Drebing Lauren E, Sun Junfeng, Berry Deborah L, Kallakury Bhaskar, Crum Christopher P, Toretsky Jeffrey A, Schlegel Richard, Üren Aykut
Abstract excerpt
Human papilloma virus (HPV) is the principal etiological agent of cervical cancer in women, and its DNA is present in virtually all of these tumors. However, exposure to the high-risk HPV types alone is insufficient for tumor development. Identifying specific collaborating factors that will lead to cervical cancer remains an unanswered question, especially because millions of women are exposed to HPV. Our earlier...
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