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Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment

1 Mar 2022

Abstract excerpt

The human hematopoietic stem cell harbors remarkable regenerative potential that can be harnessed therapeutically. During early development, hematopoietic stem cells in the fetal liver undergo active expansion while simultaneously retaining robust engraftment capacity, yet the underlying molecular program responsible for their efficient engraftment remains unclear. Here, we profile 26,407 fetal liver cells at...

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PMID: 35232959
DOI: 10.1038/s41467-022-28616-x

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