Impact of phosphodiesterase 8B gene rs4704397 variation on thyroid homeostasis in childhood obesity.

doi:10.1530/EJE-11-0703

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Article

Impact of phosphodiesterase 8B gene rs4704397 variation on thyroid homeostasis in childhood obesity.

European journal of endocrinology - 1 Feb 2012

Grandone Anna, Perrone Laura, Cirillo Grazia, Di Sessa Anna, Corona Alberto Maria, Amato Alessandra, Cresta Nicoletta, Romano Tiziana, Miraglia del Giudice Emanuele

Abstract excerpt

CONTEXT: Several studies demonstrated that obese children have higher TSH than normal-weight children. The polymorphism rs4704397 in the phosphodiesterase 8B (PDE8B) gene showed an association with TSH. OBJECTIVES: i) To assess the effect of PDE8B on TSH in obese children; ii) to dissect the role of obesity degree in modulating this association; and iii) to stratify the individual risk to show...

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PMID: 22084153
DOI: 10.1530/EJE-11-0703

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