Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy.

doi:10.1210/jc.2009-1298

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Article

Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy.

The Journal of clinical endocrinology and metabolism - 1 Nov 2009

Shields Beverley M, Freathy Rachel M, Knight Bridget A, Hill Anita, Weedon Michael N, Frayling Timothy M, Hattersley Andrew T, Vaidya Bijay

Abstract excerpt

BACKGROUND: Maternal subclinical hypothyroidism is associated with a number of adverse outcomes in pregnancy. The Endocrine Society's recent consensus guidelines have recommended treatment with T(4) for this condition in pregnancy. The single nucleotide polymorphism rs4704397 in the phosphodieste...

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Identifiers

PMID: 19820008
DOI: 10.1210/jc.2009-1298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19820008-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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