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Article

Activation of dormant secondary metabolite production by introducing neomycin resistance into the deep-sea fungus, Aspergillus versicolor ZBY-3.

Marine drugs - 29 Jul 2014

Dong Yuan, Cui Cheng-Bin, Li Chang-Wei, Hua Wei, Wu Chang-Jing, Zhu Tian-Jiao, Gu Qian-Qun

Abstract excerpt

A new ultrasound-mediated approach has been developed to introduce neomycin-resistance to activate silent pathways for secondary metabolite production in a bio-inactive, deep-sea fungus, Aspergillus versicolor ZBY-3. Upon treatment of the ZBY-3 spores with a high concentration of neomycin by proper ultrasound irradiation, a total of 30 mutants were obtained by single colony isolation. The acquired resistance of...

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Identifiers

PMID: 25076061
DOI: 10.3390/md12084326
PMCID: PMC4145319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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