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Bioinformatics analysis of genes of Streptomyces xinghaiensis (fradiae) ATCC 19609 with a focus on mutations conferring resistance to oligomycin A and its derivatives.

Journal of global antimicrobial resistance - 1 Sept 2020

Vatlin Aleksey A, Bekker Olga B, Lysenkova Ludmila N, Shchekotikhin Andrey E, Danilenko Valery N

Abstract excerpt

OBJECTIVES: The aim of this study was to obtain Streptomyces xinghaiensis (fradiae) ATCC 19609 mutants resistant to oligomycin A and its derivatives and to identify the underlying mechanism of resistance. This study was based on the premise that S. xinghaiensis ATCC 19609 contains several oligomycin A biological targets, explaining why the strain remains supersensitive to oligomycin A despite all efforts to...

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PMID: 32061812
DOI: 10.1016/j.jgar.2020.01.026

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