Article
MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9.
Age (Dordrecht, Netherlands) - 1 Feb 2013
Yang Jurong, Chen Dapeng, He Yani, Meléndez Alicia, Feng Zhe, Hong Quan, Bai Xueyuan, Li Qinggang, Cai Guangyan, Wang Jianzhong, Chen Xiangmei
Abstract excerpt
Evidence for a regulatory role of the miR-34 family in senescence is growing. However, the exact role of miR-34 in aging in vivo remains unclear. Here, we report that a mir-34 loss-of-function mutation in Caenorhabditis elegans markedly delays the age-related physiological decline, extends lifespan, and increases resistance to heat and oxidative stress. We also found that RNAi against autophagy-related genes,...
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