Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BCL-W has a fundamental role in B cell survival and lymphomagenesis

16 Jan 2017

Abstract excerpt

Compromised apoptotic signaling is a prerequisite for tumorigenesis. The design of effective therapies for cancer treatment depends on a comprehensive understanding of the mechanisms that govern cell survival. The antiapoptotic proteins of the BCL-2 family are key regulators of cell survival and are frequently overexpressed in malignancies, leading to increased cancer cell survival. Unlike BCL-2 and BCL-XL, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cell death mechanisms and regulation
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28094768
DOI: 10.1172/jci89486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BCL-W has a fundamental role in B cell survival and lymphomagenesisPMID 28094768Read ↗

B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer TherapySemantic proximity Read ↗

BCL-2 Proteins in Pathogenesis and Therapy of B-Cell Non-Hodgkin LymphomasSemantic proximity Read ↗

Molecular pathogenesis of B cell malignancy: the role of BCL-6.Semantic proximity Read ↗

MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical managementSemantic proximity Read ↗

Targeting the B-Cell Lymphoma/Leukemia 2 Family in CancerSemantic proximity Read ↗

Cell death regulation by B-cell lymphoma protein.Semantic proximity Read ↗

Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?Semantic proximity Read ↗

The Bcl-2 family: roles in cell survival and oncogenesisSemantic proximity Read ↗

Genetic Events Inhibiting Apoptosis in Diffuse Large B Cell LymphomaSemantic proximity Read ↗

BCL-2 family isoforms in apoptosis and cancerSemantic proximity Read ↗

Genetic Events Inhibiting Apoptosis in Diffuse Large B-cell LymphomaSemantic proximity Read ↗

The rise of apoptosis: targeting apoptosis in hematologic malignanciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.