Article
Beta3GnT2 (B3GNT2), a major polylactosamine synthase: analysis of B3GNT2-deficient mice.
Methods in enzymology - 1 Jan 2010
Togayachi Akira, Kozono Yuko, Kuno Atsushi, Ohkura Takashi, Sato Takashi, Hirabayashi Jun, Ikehara Yuzuru, Narimatsu Hisashi
Abstract excerpt
The polylactosamine structure is a fundamental structure of carbohydrate chains and carries a lot of biofunctional carbohydrate epitopes. To investigate the biological function of polylactosamine chains, here we generated and analyzed knockout mice lacking the gene B3gnt2, which encodes a major polylactosamine synthase. In beta1,3-N-acetylglucosaminyltransferase (B3gnt2) B3gnt2-deficient (B3gnt2-/-) mice, the...
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