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Genetic Inactivation of COPI Coatomer Separately Inhibits Vesicular Stomatitis Virus Entry and Gene Expression

10 Nov 2011

Abstract excerpt

Viruses coopt cellular membrane transport to invade cells, establish intracellular sites of replication, and release progeny virions. Recent genome-wide RNA interference (RNAi) screens revealed that genetically divergent viruses require biosynthetic membrane transport by the COPI coatomer complex for efficient replication. Here we found that disrupting COPI function by RNAi inhibited an early stage of vesicular...

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Identifiers

PMID: 22072764
DOI: 10.1128/jvi.05810-11

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Genetic Inactivation of COPI Coatomer Separately Inhibits Vesicular Stomatitis Virus Entry and Gene ExpressionPMID 22072764Read ↗

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COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.Semantic proximity Read ↗

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