Article
Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.
Science translational medicine - 9 Nov 2011
Bresler Scott C, Wood Andrew C, Haglund Elizabeth A, Courtright Joshua, Belcastro Lili T, Plegaria Jefferson S, Cole Kristina, Toporovskaya Yana, Zhao Huaqing, Carpenter Erica L, Christensen James G, Maris John M, Lemmon Mark A, Mossé Yaël P
Abstract excerpt
Activating mutations in the anaplastic lymphoma kinase (ALK) gene were recently discovered in neuroblastoma, a cancer of the developing autonomic nervous system that is the most commonly diagnosed malignancy in the first year of life. The most frequent ALK mutations in neuroblastoma cause amino acid substitutions (F1174L and R1275Q) in the intracellular tyrosine kinase domain of the intact ALK receptor....
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