Article
Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma.
Oncogene - 15 Nov 2012
Carpenter E L, Haglund E A, Mace E M, Deng D, Martinez D, Wood A C, Chow A K, Weiser D A, Belcastro L T, Winter C, Bresler S C, Vigny M, Mazot P, Asgharzadeh S, Seeger R C, Zhao H, Guo R, Christensen J G, Orange J S, Pawel B R, Lemmon M A, Mossé Y P
Abstract excerpt
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in neuroblastoma, a devastating pediatric cancer of the sympathetic nervous system. Germline and somatically acquired ALK aberrations induce increased autophosphorylation, constitutive ALK activation and increased downstream signaling. Thus, ALK is a tractable therapeutic target in neuroblastoma, likely to be susceptible to both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.