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Breast cancer screening implications of risk modeling among female relatives of ATM and CHEK2 carriers.

Cancer - 15 Apr 2020

Weidner Anne E, Liggin Mariel E, Zuniga Brenda I, Tezak Ann L, Wiesner Georgia L, Pal Tuya

Abstract excerpt

BACKGROUND: With the increasing use of multigene panel tests, pathogenic and likely pathogenic (P/LP) variants are identified more frequently in the moderate-penetrance breast cancer genes ATM and CHEK2. Lifetime breast cancer risk among women with P/LP variants in these genes generally exceeds 20%, meeting the threshold at which high-risk breast cancer screening through breast magnetic resonance imaging (MRI) is...

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Identifiers

PMID: 31967672
DOI: 10.1002/cncr.32715
PMCID: PMC7103510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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