Article
A targeted gain-of-function screen identifies genes affecting salivary gland morphogenesis/tubulogenesis in Drosophila.
Genetics - 1 Feb 2009
Maybeck Vanessa, Röper Katja
Abstract excerpt
During development individual cells in tissues undergo complex cell-shape changes to drive the morphogenetic movements required to form tissues. Cell shape is determined by the cytoskeleton and cell-shape changes critically depend on a tight spatial and temporal control of cytoskeletal behavior. We have used the formation of the salivary glands in the Drosophila embryo, a process of tubulogenesis, as an assay for...
Topics
- Animals
- Animals, Genetically Modified
- Base Sequence
- Cell Shape
- Cytoskeleton
- DNA Primers
- Drosophila
- Drosophila Proteins
- Female
- Forkhead Transcription Factors
- Gene Expression Regulation, Developmental
- Genes, Insect
- Male
- Mutation
- Nuclear Proteins
- Phenotype
- Salivary Glands
- Transcription Factors