Article
Genomic landscape and tumor mutation burden analysis of Chinese patients with sarcomatoid carcinoma of the head and neck.
Oral oncology - 1 Oct 2021
Chen Hai-Bing, Gong Xiao-Yang, Li Wang, Chen Dong-Sheng, Zhao Le-le, Li Si, Xiao Ming-Zhe, Cheng Lei, Chen Xi
Abstract excerpt
BACKGROUND: Sarcomatoid carcinoma (SC) of the head and neck (HN) is a rare disease that has both sarcomatoid and cancerous components. The genetic background and mechanisms of tumorigenesis remain largely unrevealed, and the progress of precision therapy has been limited. METHODS: Targeted DNA-based next-generation sequencing (NGS) was performed by a 539 genes panel of pan-cancer in 12 patients with SC of the HN...
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