Article
Association between interleukin 21 and Graves' disease.
Genetics and molecular research : GMR - 31 Oct 2011
Jia H Y, Zhang Z G, Gu X J, Guo T, Cui B, Ning G, Zhao Y J
Abstract excerpt
Graves' disease (GD) is an organ-specific autoimmune thyroid disease; 25-50% of GD patients will develop Graves' ophthalmopathy (GO). The etiology of GD and GO may be multifactorial, but the immune response plays a central role. Many studies have reported that IL-21 has crucial roles in autoimmune diseases. We examined whether IL-21 is associated with the development of GD and GO. The serum concentration of...
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