Article
Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Sept 2002
Stein Thor D, Johnson Jeffrey A
Abstract excerpt
Tg2576 mice overexpress a mutant form of human amyloid precursor protein with the Swedish mutation (APP(Sw)), resulting in high beta-amyloid (Abeta) levels in the brain. Despite this, amyloid plaques do not develop until 12 months of age, and there is no neuronal loss in mice as old as 16 months....
Topics
- Alzheimer Disease
- Amyloid Neuropathies
- Amyloid beta-Protein Precursor
- Animals
- Carrier Proteins
- Cell Survival
- Cerebellum
- Disease Progression
- Hippocampus
- Humans
- Immunohistochemistry