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Article

The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.

PLoS genetics - 1 Jan 2015

Chatterjee Arpita, Saha Saikat, Chakraborty Anirban, Silva-Fernandes Anabela, Mandal Santi M, Neves-Carvalho Andreia, Liu Yongping, Pandita Raj K, Hegde Muralidhar L, Hegde Pavana M, Boldogh Istvan, Ashizawa Tetsuo, Koeppen Arnulf H, Pandita Tej K, Maciel Patricia, Sarkar Partha S, Hazra Tapas K

Abstract excerpt

DNA strand-breaks (SBs) with non-ligatable ends are generated by ionizing radiation, oxidative stress, various chemotherapeutic agents, and also as base excision repair (BER) intermediates. Several neurological diseases have already been identified as being due to a deficiency in DNA end-processi...

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Source

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Identifiers

PMID: 25633985
DOI: 10.1371/journal.pgen.1004749
PMCID: PMC4310589

Genes

PNKP
ATXN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25633985-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.PMID 25633985Read ↗

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