Biochemical Properties of Pathology-Related Tau Species in Tauopathy Brains: An Extraction Protocol for Tau Oligomers and Aggregates.

Abstract excerpt

Intracellular deposition of microtubule-associated protein tau in the form of filamentous aggregates is a prominent neuropathological feature of neurodegenerative disorders termed tauopathy. Formation of filamentous tau aggregates is presumably initiated by phosphorylation and/or conformational change of protein structure followed by oligomerization and fibril extension. These processes via intermediate oligomers...

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