Article
GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity induced by anthracycline-/paclitaxel-based chemotherapy in breast cancer patients.
World journal of surgical oncology - 22 Jun 2022
Zeng Juanzi, Wu Heming, Liu Donghua, Li Liang, Li Jiaquan, Wang Qiuming, Ye Min, Huang Qingyan, Yu Zhikang, Zhang Jinfeng
Abstract excerpt
BACKGROUND: The link between glutathione S-transferase P1 (GSTP1) c.313A > G polymorphism and chemotherapy-related adverse events remains controversial. The goal of this study was to assess how this variant affected the toxicity of anthracycline-/paclitaxel-based chemotherapy in patients with breast cancer. METHODS: This study retrospectively investigated pharmacogenetic associations of GSTP1 c.313A > G with...
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