Article
An immature immunophenotype of bone marrow mast cells predicts for multilineage D816V KIT mutation in systemic mastocytosis.
Leukemia - 1 May 2012
Teodosio C, García-Montero A C, Jara-Acevedo M, Alvarez-Twose I, Sánchez-Muñoz L, Almeida J, Morgado J M, Matito A, Escribano L, Orfao A
Abstract excerpt
D816V KIT mutation of bone marrow (BM) mast cells (MC) is a common feature to systemic mastocytosis (SM) patients. Nevertheless, occurrence of the KIT mutation in BM cell compartments other than MC is associated with progression to more aggressive forms of the disease and poor outcome in indolent SM (ISM). Here, we assessed the potential association between the immunophenotype of MC and multilineage KIT mutation...
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