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Article

The immunophenotype of mast cells and its utility in the diagnostic work-up of systemic mastocytosis

7 Nov 2014

Abstract excerpt

SM comprises a heterogeneous group of disorders, characterized by an abnormal accumulation of clonal MCs in 1 or more tissues, frequently involving the skin and BM. Despite the fact that most adult patients (>90%) carry the same genetic lesion (D816V KIT mutation), the disease presents with multiple variants with very distinct clinical and biologic features, a diverse prognosis, and different therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25381388
DOI: 10.1189/jlb.5ru0614-296r

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