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Article

Mg(2+) signalling defines the group A streptococcal CsrRS (CovRS) regulon.

Molecular microbiology - 1 Aug 2007

Gryllos Ioannis, Grifantini Renata, Colaprico Annalisa, Jiang Shengmei, Deforce Emelia, Hakansson Anders, Telford John L, Grandi Guido, Wessels Michael R

Abstract excerpt

CsrRS (or CovRS) is a two-component system implicated in the control of multiple virulence determinants in the important human pathogen, group A Streptococcus (GAS). Earlier studies suggested that extracellular Mg(2+) signalled through the presumed sensor histidine kinase, CsrS. We now confirm those findings, as complementation of a csrS mutant restored Mg(2+)-dependent gene regulation. Moreover, we present...

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Identifiers

PMID: 17608796
DOI: 10.1111/j.1365-2958.2007.05818.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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