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Article

TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2015

Zepp Jarod A, Wu Ling, Qian Wen, Ouyang Wenjun, Aronica Mark, Erzurum Serpil, Li Xiaoxia

Abstract excerpt

IL-25 promotes type 2 immunity by inducing the expression of Th2-associated cytokines. Although it is known that the IL-25R (IL-17RB) recruits the adaptor protein ACT1, the IL-25R signaling mechanism remains poorly understood. While screening for IL-25R components, we found that IL-25 responses were impaired in Traf4 (-/-) cells. Administering IL-25 to Traf4 (-/-) mice resulted in blunted airway eosinophilia and...

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Source

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Identifiers

PMID: 25681341
DOI: 10.4049/jimmunol.1402647
PMCID: PMC4366881

Genes

DAZAP2
TRAF4
SMURF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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