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Influence of MTHFR C677T polymorphism on methotrexate monotherapy discontinuation in rheumatoid arthritis patients: results from the GAPAID European project.

Clinical and experimental rheumatology - 1 Jan 2000

Uribarri María, Ruiz-Larrañaga Otsanda, Arteta David, Hernández Lorena, Alcaro Maria Claudia, Martínez Antonio, Escorza-Treviño Sergio, Estonba Andone, Migliorini Paola, Czirják László, del Amo Jokin

Abstract excerpt

OBJECTIVES: Methotrexate (MTX) is the most widely prescribed drug for rheumatoid arthritis (RA) patients, but 45% of them discontinue therapy within two years, either due to inefficacy or toxicity. Several authors have reported contradictory results related to C677T polymorphism in the MTHFR gene...

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PMID: 26314492

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26314492-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Influence of MTHFR C677T polymorphism on methotrexate monotherapy discontinuation in rheumatoid arthritis patients: results from the GAPAID European project.PMID 26314492Read ↗

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