Article
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.
BMC genomics - 20 Feb 2007
Kloth Judith N, Oosting Jan, van Wezel Tom, Szuhai Karoly, Knijnenburg Jeroen, Gorter Arko, Kenter Gemma G, Fleuren Gert Jan, Jordanova Ekaterina S
Abstract excerpt
BACKGROUND: Cervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mCGH) and microsatellite marker analysis for the detection of loss of heterozygosity (LOH). Currently, high throughput methods such as array comparative genomic hybridization (array CGH), single...
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