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Article

[Recent advances of molecular mechanisms influencing prognosis of myelodysplastic syndrome - review].

Zhongguo shi yan xue ye xue za zhi - 1 Aug 2012

Guo Juan, Chang Chun-Kang, Li Xiao

Abstract excerpt

Myelodysplastic syndrome (MDS) is clonal disorder of hematopoiesis characterized by inefficient hematopoiesis, peripheral blood cytopenias, aberrant differentiation, and risk of progression to acute myeloid leukemia. Although specific karyotypic abnormalities have been found to link to MDS for decades, more recent findings have demonstrated the importance of mutations within individual genes. The recent molecular...

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PMID: 22931676

Genes

ASXL1
IDH1
IDH2
RUNX1
TET2

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