Article
Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies.
PloS one - 1 Jan 2011
Duhoux Francois P, Ameye Geneviève, Lambot Virginie, Herens Christian, Lambert Frédéric, Raynaud Sophie, Wlodarska Iwona, Michaux Lucienne, Roche-Lestienne Catherine, Labis Elise, Taviaux Sylvie, Chapiro Elise, Nguyen-Khac Florence, Khac Florence Nguyen, Struski Stéphanie, Dobbelstein Sophie, Dastugue Nicole, Lippert Eric, Speleman Frank, Van Roy Nadine, De Weer An, Rack Katrina, Talmant Pascaline, Richebourg Steven, Mugneret Francine, Tigaud Isabelle, Mozziconacci Marie-Joëlle, Laibe Sophy, Nadal Nathalie, Terré Christine, Libouton Jeanne-Marie, Decottignies Anabelle, Vikkula Miikka, Poirel Hélène A
Abstract excerpt
Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid...
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