Article
BRAF mutations in advanced cancers: clinical characteristics and outcomes.
PloS one - 1 Jan 2011
El-Osta Hazem, Falchook Gerald, Tsimberidou Apostolia, Hong David, Naing Aung, Kim Kevin, Wen Sijin, Janku Filip, Kurzrock Razelle
Abstract excerpt
BACKGROUND: Oncogenic BRAF mutations have been found in diverse malignancies and activate RAF/MEK/ERK signaling, a critical pathway of tumorigenesis. We examined the clinical characteristics and outcomes of patients with mutant (mut) BRAF advanced cancer referred to phase 1 clinic. METHODS: We reviewed the records of 80 consecutive patients with mutBRAF advanced malignancies and 149 with wild-type (wt) BRAF...
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