BRAF mutations: signaling, epidemiology, and clinical experience in multiple malignancies.

Abstract excerpt

BACKGROUND: Mutations in BRAF were first reported in 2002. Since that time, the molecular basis for oncogenic signaling has been elucidated in multiple malignancies. The development of v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors has helped improve clinical outcomes in malignant melanoma and is suggested by case reports in other malignancies. METHODS: A review of pertinent articles examining...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to BRAF gene
• Share to Mutation
• Share to Neoplasms