Article
Defining and Targeting BRAF Mutations in Solid Tumors.
Current treatment options in oncology - 27 Feb 2021
Halle Briana R, Johnson Douglas B
Abstract excerpt
OPINION STATEMENT: BRAF mutations are present in up to 8% of human cancers, and comprise a viable therapeutic target in many patients harboring these mutations. Specific BRAF-targeted therapies, such as vemurafenib, dabrafenib, and encorafenib, have transformed treatment of many BRAF-mutated cancers, producing meaningful clinical benefit with more tolerable safety profiles compared to prior standard-of-care...
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