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BRAFV600E-mutant metastatic NSCLC: disease overview and treatment landscape

16 Apr 2024

Abstract excerpt

Abstract In this review, we cover the current understanding of BRAF mutations and associated clinical characteristics in patients with metastatic NSCLC, approved and emerging treatment options, BRAF sequencing approaches, and unmet needs. The BRAFV600E mutation confers constitutive activity of the MAPK pathway, leading to enhanced growth, proliferation, and survival of tumor cells. Testing for BRAF mutations...

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PMID: 38627602
DOI: 10.1038/s41698-024-00552-7

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