Article
Mendelian randomization study of B-type natriuretic peptide and type 2 diabetes: evidence of causal association from population studies.
PLoS medicine - 1 Oct 2011
Pfister Roman, Sharp Stephen, Luben Robert, Welsh Paul, Barroso Inês, Salomaa Veikko, Meirhaeghe Aline, Khaw Kay-Tee, Sattar Naveed, Langenberg Claudia, Wareham Nicholas J
Abstract excerpt
BACKGROUND: Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but the prospective association of BNP with T2D is uncertain, and it is unclear whether the association is confounded. METHODS AND FINDINGS: We analysed the association between levels of the N-terminal fragment of pro-BNP (NT-pro-BNP) in blood...
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