Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagy Enhanced by Microtubule- and Mitochondrion-Associated MAP1S Suppresses Genome Instability and Hepatocarcinogenesis

29 Oct 2011

Abstract excerpt

Dysfunctional autophagy is associated with tumorigenesis; however, the relationship between the two processes remains unclear. In the present study, we showed that MAP1S levels immediately become elevated in response to diethylnitrosamine-induced or genome instability-driven metabolic stress in a murine model of hepatocarcinoma. Upregulation of MAP1S enhanced autophagy to remove aggresomes and dysfunctional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to CRISPR and Genetic Engineering
Share to Endoplasmic Reticulum Stress and Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22037873
DOI: 10.1158/0008-5472.can-11-2170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Autophagy Enhanced by Microtubule- and Mitochondrion-Associated MAP1S Suppresses Genome Instability and HepatocarcinogenesisPMID 22037873Read ↗

MAP1S enhances autophagy to suppress tumorigenesisSemantic proximity Read ↗

Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturationSemantic proximity Read ↗

Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patientsSemantic proximity Read ↗

Autophagy role(s) in response to oncogenes and DNA replication stressSemantic proximity Read ↗

SPOCK1 Promotes the Development of Hepatocellular CarcinomaSemantic proximity Read ↗

Defective mitosis-linked DNA damage response and chromosomal instability in liver cancerSemantic proximity Read ↗

Accumulation of microtubule associated protein tau promotes hepatocellular carcinogenesis through inhibiting autophagosome-lysosome fusionSemantic proximity Read ↗

Genetic instability occurs sooner than expected: promotion, progression and clonality during hepatocarcinogenesis in the rat.Semantic proximity Read ↗

Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases.Semantic proximity Read ↗

3‐Mercaptopyruvate sulfurtransferase represses tumour progression and predicts prognosis in hepatocellular carcinomaSemantic proximity Read ↗

Control of the Autophagy Maturation Step by the MAPK ERK and p38: Lessons from Environmental CarcinogensSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.