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Article

MAP1S enhances autophagy to suppress tumorigenesis

1 Feb 2012

Abstract excerpt

Microtubule-associated protein 1 small form (MAP1S; originally named C19ORF5) was identified as serving as linkers to connect mitochondria with microtubules for trafficking, and to bridge the autophagy machinery with microtubules and mitochondria to affect autophagosomal biogenesis and degradation. We found that MAP1S levels become elevated immediately in response to diethylnitrosamine-induced or genome...

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PMID: 22301994
DOI: 10.4161/auto.8.2.18939

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