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Defective mitosis-linked DNA damage response and chromosomal instability in liver cancer

29 May 2019

Abstract excerpt

Hepatocellular carcinoma (HCC), the most common form of liver cancer, represents a health problem in hepatic viruses-eradicating era because obesity, type 2 diabetes, and nonalcoholic steatohepatitis (NASH) are considered emerging pathogenic factors. Metabolic disorders underpin mitotic errors that lead to numerical and structural chromosome aberrations in a significant proportion of cell divisions. Here, we...

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PMID: 31152819
DOI: 10.1016/j.bbcan.2019.05.008

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